A class of drugs called COX-2 inhibitors was developed in the late 1990's, COX-2 inhibitors were generally promoted as being safer and better pain treatment than the traditional and widely used nonsteroidal anti-inflammatory drugs, known as NSAIDs, examples being aspirin and ibuprofen.
However, studies have led some researchers to questions the cardiovascular safety of Vioxx and other COX-2 inhibitors such as Celebrex.Another study published in the Medical Journal, The Lancet indicated that this group of drugs may harm the kidneys. In the article, two Spanish doctors, describe the case of a 67-year-old woman who developed kidney failure. Her kidney failure ended after she stopped taking Vioxx, leading the doctors to conclude that the kidney problems she experienced were related to the ingestion of the drug. This was the first case to show that COX-2 inhibitors may be associated with Kidney problems. It was not the Last.