Recently a report in the Journal of the American Medical Association linked Vioxx to blood clots, heart attacks, and strokes.
Other serious side effects associated with Vioxx usage are:
Serious stomach problems, such as stomach and intestinal bleeding, can occur with or without warning symptoms. These problems, if severe, could lead to hospitalization or death. Although this happens rarely, you should watch for signs that you may have this serious side effect and tell your doctor right away.
Serious allergic reactions including swelling of face, lips, tongue, and/or throat which may cause difficulty breathing or swallowing occur rarely but may require treatment right away.
Serious kidney problems occur rarely, including acute kidney failure and worsening of chronic kidney failure.
Severe liver problems occur rarely in patients taking NSAIDs. Tell your doctor if you develop symptoms of liver problems. These include nausea, tiredness, itching, tenderness in the right upper abdomen, and flu-like symptoms.
More common, non life threatening, side effects associated with VIOXX have include:
Upper and/or lower respiratory infection and/or inflammation
Nausea and/or vomiting
Heartburn, stomach pain and upset
Swelling of the legs and/or feet
High blood pressure
Urinary tract infection.